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Thesis

Ca2+ cellular compartment-specific deficits in iPSC-derived neuronal models of Parkinson's disease

Abstract:

Parkinson’s disease is a neurogenerative disease characterised by the degeneration of dopaminergic neurons of the substantia nigra. I employ induced pluripotent stem cell-derived dopaminergic neurons from patients and controls to study cytotoxic mechanisms in Parkinson’s disease.

Calcium is crucial in the regulation of many neuronal cellular processes, and even more so, in dopaminergic neurons where continuous calcium oscillations occur. This suggests that even small alterations in...

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Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
ORCID:
0000-0001-8190-4850
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:
Language:
English
Keywords:
Subjects:
Deposit date:
2023-03-01

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