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A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains.

Abstract:

Catechol-O-methyltransferase (COMT) is a key enzyme for dopamine catabolism and COMT is a candidate gene for human psychiatric disorders. In mouse it is located on chromosome 16 in a large genomic region of extremely low variation among the classical inbred strains, with no confirmed single nucleotide polymorphisms (SNPs) between strains C57BL/6J and DBA/2J within a 600-kB window. We found a B2 SINE in the 3' untranslated region (UTR) of Comt1 which is present in C57BL/6J (Comt1(B2i)) and oth...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Genes, brain, and behavior
Volume:
9
Issue:
8
Pages:
925-932
Publication date:
2010-11-05
DOI:
EISSN:
1601-183X
ISSN:
1601-1848
URN:
uuid:ba0fc5eb-c049-4304-a39f-c98a01f55f86
Source identifiers:
139417
Local pid:
pubs:139417

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