Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma

Journal article

Purpose: Pancreatic stellate cells (PSC) drive desmoplasia in pancreatic cancer. Our study analyzed both tumor and PSC, since interaction of these cell types may promote tumor progression. Results: SPARC was expressed predominantly in the peritumoral and distal stroma. SPARC in distal stroma correlated inversely with overall survival of the patients with LAPC (p = 0.013) with a relative hazard of 2.23 (95% CI, 1.05 to 4.72; p = 0.036). TGFβ1 in the tumor was also a negative prognostic factor ...

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Authors: Mantoni, T; Schendel, R; Rödel, F; Niedobitek, G; Al-Assar, O

• Journal: Cancer Biology and Therapy
• Volume: 7
• Issue: 11
• Pages: 1807-1816
• Publication date: 2008-11-01
• EISSN: 1555-8576
• ISSN: 1538-4047
• Language: English
• Keywords: Pancreatic stellate cells; Locally advanced; SPARC; Pancreatic cancer; Stroma; Chemoradiation