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ATM/ATR-dependent responses to dysfunctional telomeres at the G2/M transition

Abstract:

Mammalian telomeres are nucleoprotein complexes at the end of chromosomes containing a specific protein complex, called shelterin. Shelterin protects chromosome ends from the DNA damage response (DDR), by facilitating the formation of a telomeric capping structure, called the T-loop. During their elongation in S phase, telomeres become transiently uncapped and can be sensed as DNA damage in G2 phase. This leads to the recruitment of DDR factors, such as phosphorylated histone H2AX (γH2AX),...

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Institution:
University of Oxford
Research group:
Telomeres and genome stability group
Oxford college:
Queen's College, The
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

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Role:
Supervisor
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Funding agency for:
Maria Thanasoula
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:b9f806e3-88e5-4dc4-b2e9-8ecf854249d1
Local pid:
ora:6001
Language:
English
Keywords:
Subjects:

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