Journal article icon

Journal article

ADGRE1 (EMR1, F4/80) Is a rapidly-evolving gene expressed in mammalian monocyte-macrophages

Abstract:

The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-macrophage marker in mice, but its value as a macrophage marker in other species is unclear, and has even been questioned. ADGRE1 is a seven transmembrane G protein-coupled receptor with an extracellular domain containing repeated Epidermal Growth Factor (EGF)-like calcium binding domains. Using a new monoclonal antibody, we demonstrated that ADGRE1 is a myeloid differentiation marker in pigs, absent from proge...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.3389/fimmu.2018.02246

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-9341-2562
Expand authors...
More from this funder
Funding agency for:
Bush, SJ
Mater Foundation More from this funder
Newton Fund More from this funder
Expand funders...
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
OCT
Pages:
2246
Publication date:
2018-10-01
Acceptance date:
2018-09-10
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Pubs id:
pubs:929604
URN:
uri:b9f6eb24-ea9a-46cb-a928-d1f780ec4122
UUID:
uuid:b9f6eb24-ea9a-46cb-a928-d1f780ec4122
Local pid:
pubs:929604

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP