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The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis.

Abstract:

Craniopharyngiomas are epithelial, sellar tumours with adamantinomatous (aCP) and papillary (pCP) subtypes. The aCP type usually occurs during childhood and pCP in middle-aged adults; aCPs often contain mutations in CTNNB1, encoding β-catenin, a component of the adherens junction and a mediator of Wnt signalling. No such mutational event has been associated with pCPs, where the BRAF gene appears to be more important. In a large series of 95 craniopharyngiomas, we show that the aCP subtype har...

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Publisher copy:
10.1007/s12022-014-9341-8

Authors


Larkin, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Ansorge, O More by this author
Grossman, AB More by this author
Journal:
Endocrine pathology
Publication date:
2014-10-05
DOI:
EISSN:
1559-0097
ISSN:
1046-3976
URN:
uuid:b9f57bc0-ccf0-4a16-afac-831fdf980f55
Source identifiers:
488216
Local pid:
pubs:488216
Language:
English

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