Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.

Journal article

We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic cardiac glycoside receptors by digoxin with resultant inhibition of active cation transport. These effects correlate well with the patients' clinical responses to treatment. During long-term treatment, howe...

Expand abstract

Authors: Aronson, J; Ford, A; Grahame-Smith, D

• Publication status: Published
• Journal: Klinische Wochenschrift
• Volume: 59
• Issue: 24
• Pages: 1323-1332
• Publication date: 1981-12-01
• DOI: 10.1007/bf01720552
• EISSN: 1432-1440
• ISSN: 0023-2173
• Language: English
• Keywords: Electrolytes; Digoxin; Ion Channels; Sodium-Potassium-Exchanging ATPase; Hemodynamics; Erythrocytes; Humans; Heart Rate; Atrial Fibrillation; Heart Failure