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Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.

Abstract:

We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic cardiac glycoside receptors by digoxin with resultant inhibition of active cation transport. These effects correlate well with the patients' clinical responses to treatment. During long-term treatment, howe...

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Publication status:
Published

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Publisher copy:
10.1007/bf01720552

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Role:
Author
Journal:
Klinische Wochenschrift
Volume:
59
Issue:
24
Pages:
1323-1332
Publication date:
1981-12-05
DOI:
EISSN:
1432-1440
ISSN:
0023-2173
URN:
uuid:b9ecad41-778b-4da6-8917-0f269365c1dd
Source identifiers:
322110
Local pid:
pubs:322110

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