A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.

Journal article

The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here, we introduce a rich, intuitive and biologically realistic genotype-phenotype (GP) map that serves as a model of self-assembling biological structures, such as protein complexes, and remains computationally and analytically tractable. Our GP map arises naturally from the self-assembly of polyomino structures on a two-dimensional lattice and exhibits a number of properties: redundancy ...

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Authors: Greenbury, S; Johnston, I; Louis, A; Ahnert, SE

• Publication status: Published
• Journal: Journal of the Royal Society, Interface / the Royal Society
• Volume: 11
• Issue: 95
• Pages: 20140249
• Publication date: 2014-06-01
• DOI: 10.1098/rsif.2014.0249
• EISSN: 1742-5662
• ISSN: 1742-5689
• Language: English
• Keywords: Models, Molecular; Protein Folding; Proteins; Evolution, Molecular; Protein Structure, Quaternary