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Journal article

Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse

Abstract:

The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1003166

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
9
Issue:
1
Pages:
e1003166
Publication date:
2013-01-03
Acceptance date:
2012-10-26
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:b9e2981b-0d8d-4a06-850b-c26a0bff02bd
Source identifiers:
384798
Local pid:
pubs:384798

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