Journal article
Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse
- Abstract:
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The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 966.7KB)
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- Publisher copy:
- 10.1371/journal.pgen.1003166
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- e1003166
- Publication date:
- 2013-01-03
- Acceptance date:
- 2012-10-26
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
- Source identifiers:
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384798
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:b9e2981b-0d8d-4a06-850b-c26a0bff02bd
- Local pid:
- pubs:384798
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- McMurray et al
- Copyright date:
- 2013
- Notes:
- © 2013 McMurray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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