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Stereoselective synthesis of cyclohexanes via an iridium catalyzed (5 + 1) annulation strategy

Abstract:
An iridium catalyzed method for the synthesis of functionalized cyclohexanes from methyl ketones and 1,5-diols is described. This process operates by two sequential hydrogen borrowing reactions, providing direct access to multisubstituted cyclic products with high levels of stereocontrol. This methodology represents a novel (5 + 1) strategy for the stereoselective construction of the cyclohexane core.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/jacs.8b07776

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
ORCID:
0000-0002-3759-061X
More by this author
ORCID:
0000-0002-4966-0419
Stevenson, NG More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
Oxford college:
Magdalen College
ORCID:
0000-0001-7088-6626
More from this funder
Funding agency for:
Akhtar, WM
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
38
Pages:
11916-11920
Publication date:
2018-09-13
Acceptance date:
2018-09-08
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:920866
URN:
uri:b9d106e4-374a-4c9a-81e3-adcd4a4d8885
UUID:
uuid:b9d106e4-374a-4c9a-81e3-adcd4a4d8885
Local pid:
pubs:920866
Language:
English
Keywords:

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