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The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription.

Abstract:

Up-regulation of utrophin gene expression is recognized as a plausible therapeutic approach in the treatment of Duchenne muscular dystrophy (DMD). We have designed and engineered new zinc finger-based transcription factors capable of binding and activating transcription from the promoter of the dystrophin-related gene, utrophin. Using the recognition 'code' that proposes specific rules between zinc finger primary structure and potential DNA binding sites, we engineered a new gene named 'Jazz'...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301204

Authors


Fanciulli, M More by this author
Tinsley, JM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Journal:
Gene therapy
Volume:
7
Issue:
12
Pages:
1076-1083
Publication date:
2000-06-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:b9c40251-7add-410e-ae0e-f62d02f64026
Source identifiers:
106589
Local pid:
pubs:106589

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