The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to severe psoriatic arthritis: the 3-arm parallel group SPEED randomized controlled trial

Watson, M; Tillett, W; Jadon, D; Massa, MS; Francis, A; Gullick, N; Rombach, I; Sinomati, Y; Tucker, L; Coates, LC

Journal article

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to severe psoriatic arthritis: the 3-arm parallel group SPEED randomized controlled trial

Abstract:: Objectives:: The aim of the Severe Psoriatic arthritis – Early intervEntion to control Disease trial is to compare outcomes in psoriatic arthritis (PsA) patients with poor prognostic factors treated with standard step-up conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), combination csDMARDs or a course of early biologics. Design:: This multicentre UK trial was embedded within the MONITOR-PsA cohort, which uses a trial within cohort design. Methods and analysis:: Patien...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Watson, M., Tillett, W., Jadon, D., Massa, M. S., Francis, A., Gullick, N., Rombach, I., Sinomati, Y., Tucker, L., & Coates, L. C. (2024). The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to severe psoriatic arthritis: the 3-arm parallel group SPEED randomized controlled trial. Therapeutic Advances in Musculoskeletal Disease, 16.

MLA Style

Watson, M., et al. “The Protocol of a Clinical Effectiveness Trial Comparing Standard Step-up Care, Early Combination DMARD Therapy and Early Use of TNF Inhibitors for the Treatment of Moderate to Severe Psoriatic Arthritis: the 3-Arm Parallel Group SPEED Randomized Controlled Trial.” Therapeutic Advances in Musculoskeletal Disease, vol. 16, SAGE Publications, 2024.

Chicago Style

Watson, M, W Tillett, D Jadon, MS Massa, A Francis, N Gullick, I Rombach, Y Sinomati, L Tucker, and LC Coates. 2024. “The Protocol of a Clinical Effectiveness Trial Comparing Standard Step-up Care, Early Combination DMARD Therapy and Early Use of TNF Inhibitors for the Treatment of Moderate to Severe Psoriatic Arthritis: the 3-Arm Parallel Group SPEED Randomized Controlled Trial.” Therapeutic Advances in Musculoskeletal Disease 16.
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