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H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization.

Abstract:

The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorporation properties. Z.2.2 mRNA is found in all human cell lines and tissues with highest levels in brain. We show the proper splicing and in vivo existence of this variant protein...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gks267

Authors


Bönisch, C More by this author
Schneider, K More by this author
Pünzeler, S More by this author
Wiedemann, SM More by this author
Bielmeier, C More by this author
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Deutsche Forschungsgemeinschaft More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
13
Pages:
5951-5964
Publication date:
2012-07-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:b9bae411-56f9-44c7-b678-d685af72f8d0
Source identifiers:
322961
Local pid:
pubs:322961

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