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H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization.

Abstract:

The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorporation properties. Z.2.2 mRNA is found in all human cell lines and tissues with highest levels in brain. We show the proper splicing and in vivo existence of this variant protein...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/nar/gks267

Authors


Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
13
Pages:
5951-5964
Publication date:
2012-07-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
322961
Language:
English
Keywords:
UUID:
uuid:b9bae411-56f9-44c7-b678-d685af72f8d0
Local pid:
pubs:322961
Deposit date:
2013-11-17

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