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Thesis

TEX264 in DNA replication and genome stability

Abstract:

DNA damage drives numerous human pathologies, including cancer and ageing. However, it can also be exploited in cancer therapy, where most chemotherapeutics exert their effects by inducing DNA damage. A common type of DNA lesion induced by chemotherapeutics is DNA-protein crosslinks (DPC). DPCs are also very common endogenous DNA lesions which impede DNA replication, transcription, and mitosis. However, very little is known about the mechanisms by which they are repaired.

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-5522-021X
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Name:
Cancer Research UK
Funder identifier:
http://dx.doi.org/10.13039/501100000289
Programme:
CRUK DPhil Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2020-08-10

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