Journal article icon

Journal article

Melanosome-autonomous regulation of size and number: The OA1 receptor sustains PMEL expression

Abstract:

Summary: Little is known as to how cells ensure that organelle size and number are coordinated to correctly couple organelle biogenesis to the demands of proliferation or differentiation. OA1 is a melanosome-associated G-protein-coupled receptor involved in melanosome biogenesis during melanocyte differentiation. Cells lacking OA1 contain fewer, but larger, mature melanosomes. Here, we show that OA1 loss of function reduces both the basal expression and the α-melanocyte-stimulating hormone/cA...

Expand abstract

Actions


Access Document


Publisher copy:
10.1111/pcmr.12239

Authors


Expand authors...
Publisher:
Blackwell Publishing Ltd
Journal:
Pigment Cell and Melanoma Research
Volume:
27
Issue:
4
Pages:
565-579
Publication date:
2014-01-01
DOI:
EISSN:
1755-148X
ISSN:
1755-1471
URN:
uuid:b9b5646a-8b49-48a1-817e-85d04a2accf0
Source identifiers:
472040
Local pid:
pubs:472040

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP