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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Abstract:

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance, five of which are novel. Overall, the common variants associated with se...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000504

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Medical Research Council More from this funder
British Heart Foundation More from this funder
Wellcome Trust More from this funder
Barts and The London Charity More from this funder
GlaxoSmithKline More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
5
Issue:
6
Pages:
e1000504
Publication date:
2009-06-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:b9b0621a-0f93-4c65-8b8b-faa2d0d0e49f
Source identifiers:
18608
Local pid:
pubs:18608

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