Journal article icon

Journal article

Phosphorylated KDR can be located in the nucleus of neoplastic cells.

Abstract:

KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies on animal cell lines reported in the literature have demonstrated that, following stimulation with VEGF, KDR is actually translocated within the nucleus. Our aim was to investiga...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.cr.7310012

Authors


Blazquez, C More by this author
Micklem, K More by this author
Harris, AL More by this author
Gatter, KC More by this author
Expand authors...
Journal:
Cell research
Volume:
16
Issue:
1
Pages:
93-98
Publication date:
2006-01-05
DOI:
EISSN:
1748-7838
ISSN:
1001-0602
URN:
uuid:b9a50700-a1c5-46c2-9e5e-b3caf961ea43
Source identifiers:
118989
Local pid:
pubs:118989

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP