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Journal article

The influence of conjugation variables on the design and immunogenicity of a glycoconjugate vaccine against Salmonella Typhi.

Abstract:

In recent years there have been major efforts to develop glycoconjugate vaccines based on the Vi polysaccharide that will protect against Salmonella enterica Typhi infections, particularly typhoid fever, which remains a major public health concern in low-income countries. The design of glycoconjugate vaccines influences the immune responses they elicit. Here we systematically test the response in mice to Vi glycoconjugates that differ in Vi chain length (full-length and fragmented), carrier p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0189100

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Novartis Vaccines Institute for Global Health More from this funder
GlaxoSmithKline More from this funder
University of Birmingham. More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
12
Issue:
12
Pages:
e0189100
Publication date:
2017-12-05
Acceptance date:
2017-11-18
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pubs id:
pubs:817422
URN:
uri:b99e91bb-6198-4993-9a74-46718fff7f04
UUID:
uuid:b99e91bb-6198-4993-9a74-46718fff7f04
Local pid:
pubs:817422

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