Journal article

### The need for large-scale randomized evidence.

Abstract:

The reliable detection of moderate differences in major health outcomes that arise as a result of treatment requires large-scale randomized evidence (and the appropriate interpretation of this evidence once it has been generated). This may take the form of a single mega-trial or, exceptionally, a meta-analysis of many smaller randomized trials may provide worthwhile information. Small or non-randomized studies cannot generally be trusted to distinguish reliably between a moderate benefit, a m...

Publication status:
Published

### Authors

Baigent, C More by this author
Journal:
British journal of clinical pharmacology
Volume:
43
Issue:
4
Pages:
349-353
Publication date:
1997-04-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:b966b7c7-51f4-487a-8379-2ceb966b4588
Source identifiers:
49499
Local pid:
pubs:49499
Language:
English
Keywords: