Journal article
Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine
- Abstract:
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A general route which provides direct access to pyroglutamates from tetramates, making use of Suzuki coupling on an enol mesylate, followed by reduction, is reported. This work permits direct scaffold hopping from tetramate to substituted pyroglutamates. Some compounds in the library showed modest antibacterial activity against Gram-positive bacteria.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.joc.9b01432
Authors
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 84
- Issue:
- 16
- Pages:
- 10257-10279
- Publication date:
- 2019-07-09
- Acceptance date:
- 2019-07-29
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
- Pmid:
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31287955
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1037383
- UUID:
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uuid:b964e511-15eb-4663-98d0-15a70cbd4b70
- Local pid:
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pubs:1037383
- Source identifiers:
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1037383
- Deposit date:
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2019-08-06
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 American Chemical Society.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: https://doi.org/10.1021/acs.joc.9b01432
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