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Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: case control and family-based studies.

Abstract:

The thyrotropin receptor (TSH-R) gene is a candidate for genetic susceptibility to Graves' disease (GD). Previous case control studies investigating allelic association of a polymorphism at position 253 (C253 to A253) of the TSH-R gene have shown conflicting results. We genotyped two independent case control datasets (UK Caucasian and Hong Kong Chinese), for the A253 polymorphism. The Transmission Disequilibrium Test was also used in a third family-based dataset that included 89 UK Caucasian ...

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Publisher copy:
10.1089/thy.1998.8.777

Authors


Allahabadia, A More by this author
Heward, JM More by this author
Mijovic, C More by this author
Carr-Smith, J More by this author
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Journal:
Thyroid : official journal of the American Thyroid Association
Volume:
8
Issue:
9
Pages:
777-780
Publication date:
1998-09-05
DOI:
EISSN:
1557-9077
ISSN:
1050-7256
URN:
uuid:b956d13d-62aa-4b15-a465-f1f17d3e1993
Source identifiers:
176357
Local pid:
pubs:176357

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