Journal article icon

Journal article

Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.

Abstract:

Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of beta-lactam antibiotics, some of which are used clinically. CarB displays sequence homology with members of the crotonase family including enoyl-CoA hydratase (crotonase) and methylmalonyl-CoA decarboxylase. The CarB reaction has been proposed to comprise condensation of acetyl coenzyme A (AcCoA) and glutamate semi-aldehyde...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m311824200

Authors


Sleeman, MC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
The Journal of biological chemistry
Volume:
279
Issue:
8
Pages:
6730-6736
Publication date:
2004-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:b95439a1-2201-45ea-84e9-6321559080da
Source identifiers:
32542
Local pid:
pubs:32542

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP