Matrix metalloproteinases as profibrotic factors in terminal ileum in Crohn's disease.

Journal article

BACKGROUND: Returning stenosis in Crohn's disease (CD) patients is poorly understood. After resection, newly developed strictures are seen within 10 years in 50% to 70%. Matrix metalloproteinases (MMPs) are involved in matrix-turnover processes. This study analyzes spatial expression of MMP-1, MMP-3, MMP-9, tissue inhibitor of MMP-1, and collagen III to get better insight in tissue remodeling of terminal ileum of CD patients. METHODS: Expressions were analyzed on mRNA and the protein level (...

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Authors: Warnaar, N; Hofker, H; Maathuis, M; Niesing, J; Bruggink, A

• Publication status: Published
• Journal: Inflammatory bowel diseases
• Volume: 12
• Issue: 9
• Pages: 863-869
• Publication date: 2006-09-01
• DOI: 10.1097/01.mib.0000231568.43065.ed
• EISSN: 1536-4844
• ISSN: 1078-0998
• Language: English
• Keywords: Female; Humans; Matrix Metalloproteinase 3; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Matrix Metalloproteinases; Matrix Metalloproteinase 1; Crohn Disease; RNA, Messenger; Constriction, Pathologic; Tissue Inhibitor of Metalloproteinase-1; Middle Aged; Adult; Male; Up-Regulation; Ileum; Recurrence; Interleukin-16; Gene Expression Regulation, Enzymologic