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Journal article

Genetic correction of PSA values using sequence variants associated with PSA levels.

Abstract:

Measuring serum levels of the prostate-specific antigen (PSA) is the most common screening method for prostate cancer. However, PSA levels are affected by a number of factors apart from neoplasia. Notably, around 40% of the variability of PSA levels in the general population is accounted for by inherited factors, suggesting that it may be possible to improve both sensitivity and specificity by adjusting test results for genetic effects. To search for sequence variants that associate with PSA ...

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Publication status:
Published

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Authors


Gudmundsson, J More by this author
Besenbacher, S More by this author
Gudbjartsson, DF More by this author
Olafsson, I More by this author
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Journal:
Science translational medicine
Volume:
2
Issue:
62
Pages:
62ra92
Publication date:
2010-12-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:b93a2708-6313-40f7-92c8-0f2889c2c84a
Source identifiers:
120599
Local pid:
pubs:120599

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