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The pulmonary vasculature - lessons from Tibetans and from rare diseases of oxygen sensing.

Abstract:

The human pulmonary circulation loses its natural distensibility during sustained hypoxia, leading to pulmonary arterial hypertension and a much higher workload for the right ventricle. The hypoxia-inducible factor (HIF) pathway is implicated in this pulmonary vascular response to continued hypoxia by animal studies, and additionally, by rare human diseases where the pathway is upregulated. However, there are no known human genetic diseases downregulating HIF. Tibetans, though, demonstrate bl...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Experimental physiology
Pages:
n/a-n/a
Publication date:
2014-09-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:b92c6d4a-c591-4b89-a17f-a3d0470a0184
Source identifiers:
485045
Local pid:
pubs:485045
Language:
English

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