Associations of proinflammatory cytokines with the risk of recurrent stroke.

Journal article

BACKGROUND AND PURPOSE: There are few reports on proinflammatory cytokines and risk of primary or recurrent stroke. We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-alpha) with recurrent stroke in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). METHODS: We performed a nested case-control study of 591 strokes (472 ischemic, 83 hemorrhagic, 36 unknown subtype) occurring during a randomiz...

Expand abstract

Authors: Welsh, P; Lowe, G; Chalmers, J; Campbell, D; Rumley, A

• Journal: Stroke; a journal of cerebral circulation
• Volume: 39
• Issue: 8
• Pages: 2226-2230
• Publication date: 2008-08-01
• DOI: 10.1161/strokeaha.107.504498
• EISSN: 1524-4628
• ISSN: 0039-2499
• Language: English
• Keywords: Interleukin-18; Fibrinogen; Tumor Necrosis Factor-alpha; Recurrence; Cerebral Hemorrhage; Biological Markers; Male; C-Reactive Protein; Cytokines; Aged; Stroke; Multivariate Analysis; Acute-Phase Reaction; Middle Aged; Interleukin-6; Female; Brain Ischemia; Humans; Case-Control Studies; Risk Factors