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The interaction of phospholipase A2 with a phospholipid bilayer: coarse-grained molecular dynamics simulations.

Abstract:

A number of membrane-active enzymes act in a complex environment formed by the interface between a lipid bilayer and bulk water. Although x-ray diffraction studies yield structures of isolated enzyme molecules, a detailed characterization of their interactions with the interface requires a measure of how deeply such a membrane-associated protein penetrates into a lipid bilayer. Here, we apply coarse-grained (CG) molecular dynamics (MD) simulations to probe the interaction of porcine pancreati...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.107.123190

Authors


Journal:
Biophysical journal
Volume:
95
Issue:
4
Pages:
1649-1657
Publication date:
2008-08-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
100743
Language:
English
Keywords:
Pubs id:
pubs:100743
UUID:
uuid:b91463f0-1f6b-4152-bd46-ed7dae98bb45
Local pid:
pubs:100743
Deposit date:
2012-12-19

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