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A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

Abstract:

Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by entrapment of the median nerve at the level of the wrist. It is the commonest entrapment neuropathy, with estimates of prevalence ranging between 5–10%. Here, we undertake a genome-wide association study (GWAS) of an entrapment neuropathy, using 12,312 CTS cases and 389,344 controls identified in UK Biobank. We discover 16 susceptibility loci for CTS with p ≺ 5 × 10−8. We identify likely causal genes in the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-019-08993-6

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
ORCID:
0000-0003-4944-123X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
ORCID:
0000-0001-7759-0211
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Medical School Offices
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0001-9237-5878
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Publisher:
Springer Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 1030
Publication date:
2019-03-04
Acceptance date:
2019-02-13
DOI:
EISSN:
2041-1723
Pubs id:
pubs:972238
URN:
uri:b8fe3f31-f509-49db-8dff-a9fca5f54993
UUID:
uuid:b8fe3f31-f509-49db-8dff-a9fca5f54993
Local pid:
pubs:972238
Language:
English
Keywords:

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