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Journal article

Influence of soluble or matrix-bound isoforms of vascular endothelial growth factor-A on tumor response to vascular-targeted strategies.

Abstract:

Antiangiogenic therapy based on blocking the actions of vascular endothelial growth factor-A (VEGF) can lead to "normalization" of blood vessels in both animal and human tumors. Differential expression of VEGF isoforms affects tumor vascular maturity, which could influence the normalization process and response to subsequent treatment. Fibrosarcoma cells expressing only VEGF120 or VEGF188 isoforms were implanted either subcutaneously (s.c.) or in dorsal skin-fold "window" chambers in SCID mic...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.28281

Authors


Akerman, S More by this author
Daniel, RA More by this author
Reyes-Aldasoro, CC More by this author
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Journal:
International journal of cancer. Journal international du cancer
Volume:
133
Issue:
11
Pages:
2563-2576
Publication date:
2013-12-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:b8fd745a-e877-4dce-93c0-ac6d422c95fc
Source identifiers:
415312
Local pid:
pubs:415312

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