- Abstract:
-
Antiangiogenic therapy based on blocking the actions of vascular endothelial growth factor-A (VEGF) can lead to "normalization" of blood vessels in both animal and human tumors. Differential expression of VEGF isoforms affects tumor vascular maturity, which could influence the normalization process and response to subsequent treatment. Fibrosarcoma cells expressing only VEGF120 or VEGF188 isoforms were implanted either subcutaneously (s.c.) or in dorsal skin-fold "window" chambers in SCID mic...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/ijc.28281
-
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- Journal:
- International journal of cancer. Journal international du cancer
- Volume:
- 133
- Issue:
- 11
- Pages:
- 2563-2576
- Publication date:
- 2013-12-05
- DOI:
- EISSN:
-
1097-0215
- ISSN:
-
0020-7136
- URN:
-
uuid:b8fd745a-e877-4dce-93c0-ac6d422c95fc
- Source identifiers:
-
415312
- Local pid:
- pubs:415312
- Copyright date:
- 2013
Journal article
Influence of soluble or matrix-bound isoforms of vascular endothelial growth factor-A on tumor response to vascular-targeted strategies.
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