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5-Formylcytosine does not change the global structure of DNA

Abstract:

The mechanism by which 5-formylcytosine (fC) is recognised by enzymes involved in epigenetic modification and reading of DNA is not known, and recently an unusual DNA structure (F-DNA) was proposed as the basis for enzyme recognition of clusters of fC. We used NMR and X-ray crystallography to compare several modified DNA duplexes with the unmodified analogues and show that in the crystal state they all belong to the A-family, but in solution they are all members of the B-family. Contrary to t...

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Publication status:
*Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nsmb.3411

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Singleton, D More by this author
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Funding agency for:
Hardwick, JS
Carmen L. Buck Endowment More from this funder
University of Kentucky More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
24
Pages:
544–552
Publication date:
2017-05-05
Acceptance date:
2017-04-13
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pubs id:
pubs:695415
URN:
uri:b8fcbbdc-1ce3-4d39-93ca-dbc30b12de76
UUID:
uuid:b8fcbbdc-1ce3-4d39-93ca-dbc30b12de76
Local pid:
pubs:695415
Keywords:

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