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Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution.

Abstract:

CD200 is a widely distributed membrane glycoprotein that regulates myeloid cell activity through its interaction with an inhibitory receptor (CD200R). The interaction is of interest as a target for treating excessive inflammation and for treating leukemia. There are closely related proteins to CD200R that give activating signals making this a "paired receptor." We report X-ray crystallography structures for the inhibitory CD200R, the activating receptor CD200RLa, and a complex between CD200R ...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2013.03.008

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
21
Issue:
5
Pages:
820-832
Publication date:
2013-05-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:b8f71a73-a9b6-4401-b93c-63835136a032
Source identifiers:
395920
Local pid:
pubs:395920

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