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Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford.

Abstract:
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

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Publisher copy:
10.1080/02688690802448335

Authors


Pereira, EA More by this author
Muthusamy, KA More by this author
De Pennington, N More by this author
Journal:
British journal of neurosurgery
Volume:
22 Suppl 1
Issue:
SUPPL. 1
Pages:
S41-S44
Publication date:
2008
DOI:
EISSN:
1360-046X
ISSN:
0268-8697
URN:
uuid:b8f67980-5fdc-4301-953c-7ddf4028ffc0
Source identifiers:
148891
Local pid:
pubs:148891

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