- Abstract:
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Background Infection with the gram-negative bacillus Burkholderia pseudomallei (melioidosis) is an important cause of pneumosepsis in Southeast Asia and has a mortality of up to 40%. We aimed to assess the role of platelets in the host response against B. pseudomallei infection. Methods Association between platelet counts and mortality was determined in 1160 patients with culture-proven melioidosis. Mice treated with (low- or high-dose) platelet-depleting an... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 726.0kb)
-
- Publisher copy:
- 10.1093/infdis/jiy541
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Volume:
- 219
- Issue:
- 4
- Pages:
- 648–659
- Publication date:
- 2018-10-11
- Acceptance date:
- 2018-09-26
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pubs id:
-
pubs:929656
- URN:
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uri:b8f0bc33-5c7f-4a58-ab94-146b5472393a
- UUID:
-
uuid:b8f0bc33-5c7f-4a58-ab94-146b5472393a
- Local pid:
- pubs:929656
- Language:
- English
- Keywords:
- Copyright holder:
- Birnie et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Thrombocytopenia impairs host defense against Burkholderia pseudomallei (Melioidosis)
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