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Thrombocytopenia impairs host defense against Burkholderia pseudomallei (Melioidosis)

Abstract:
Background Infection with the gram-negative bacillus Burkholderia pseudomallei (melioidosis) is an important cause of pneumosepsis in Southeast Asia and has a mortality of up to 40%. We aimed to assess the role of platelets in the host response against B. pseudomallei infection. Methods Association between platelet counts and mortality was determined in 1160 patients with culture-proven melioidosis. Mice treated with (low- or high-dose) platelet-depleting an... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/infdis/jiy541

Authors


Claushuis, TAM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0001-7240-5320
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
ORCID:
0000-0003-2309-1171
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
219
Issue:
4
Pages:
648–659
Publication date:
2018-10-11
Acceptance date:
2018-09-26
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:929656
URN:
uri:b8f0bc33-5c7f-4a58-ab94-146b5472393a
UUID:
uuid:b8f0bc33-5c7f-4a58-ab94-146b5472393a
Local pid:
pubs:929656

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