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Attachment of repeated sequences to the nuclear cage.

Abstract:

Nuclear DNA is probably organized into loops by attachment to a sub-structure in vivo. When HeLa cells are lysed in Triton and 2M NaCl the resulting nucleoids contain naked DNA which is supercoiled so the loops must remain intact. We have attempted to identify sequences responsible for attaching these loops to the nuclear sub-structure by progressively detaching DNA with various nucleases. Fragments at the 5' end of the ribosomal RNA locus, and a variety of transcribed and repeated sequences,...

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Publication status:
Published

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Publisher copy:
10.1093/nar/12.17.6709

Authors


Jackson, DA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nucleic acids research
Volume:
12
Issue:
17
Pages:
6709-6726
Publication date:
1984-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:b8eb2ff1-bcd4-4ac9-991d-0ecdffa00f2f
Source identifiers:
2320
Local pid:
pubs:2320

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