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Computational models of the heart and their use in assessing the actions of drugs.

Abstract:

Models of cardiac cells are sufficiently well developed to answer questions concerning the actions of drugs on repolarization and the initiation of arrhythmias. These models can be used to characterize drug-receptor action profiles that would be expected to avoid arrhythmia and so help to identify drugs that may be safer. Several examples of such action profiles are presented here, including a recently-developed blocker of persistent sodium current, ranolazine. The models have also been incor...

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Publication status:
Published

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Publisher copy:
10.1254/jphs.cr0070042

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Journal of pharmacological sciences
Volume:
107
Issue:
2
Pages:
107-117
Publication date:
2008-06-05
DOI:
EISSN:
1347-8648
ISSN:
1347-8613
URN:
uuid:b8cf3289-1997-44d4-baa5-f763bc934225
Source identifiers:
237444
Local pid:
pubs:237444

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