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Thesis

Defining mechanisms of NOD2 receptor function in myeloid cells

Abstract:

Pattern recognition receptors (PRRs) recognise foreign antigen to direct innate and adaptive immune responses against invading pathogens. Polymorphisms in the PRR NOD2 represent the strongest genetic risk factor for the inflammatory bowel disease Crohn’s, and thus this bacterial sensor is the focus of particular research interest. By recapitulating the hypoxic conditions encountered at sites of inflammation, this study utilised quantitative phosphoproteomics to identify novel downstre...

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Division:
MSD
Department:
Biomedical Services
Role:
Author

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Role:
Supervisor
Oxford NIHR Biomedical Research Centre More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:b8ce7b62-03d2-41cc-b3a3-fb5995790a2e
Deposit date:
2018-07-01

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