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Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.

Abstract:

Members of the AFF (AF4/FMR2) family of putative transcription factors are involved in infant acute leukaemia and intellectual disability (ID), although very little is known about their transcriptional targets. For example, deletion of human lymphoid nuclear protein related to AF4/AFF member 3 (LAF4/AFF3) is known to cause severe neurodevelopmental defects, and silencing of the gene is also associated with ID at the folate-sensitive fragile site (FSFS) FRA2A; yet the normal function of this g...

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Publication status:
Published

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Authors


Oliver, PL More by this author
Finelli, MJ More by this author
Lickiss, T More by this author
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Journal:
PloS one
Volume:
9
Issue:
8
Pages:
e105933
Publication date:
2014
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:b8afd852-3291-4918-89e5-081c8eebacd6
Source identifiers:
482532
Local pid:
pubs:482532
Language:
English

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