The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.

Journal article

The LMO2 gene encodes a LIM-only protein and is a target of chromosomal translocations in human T-cell leukemia. Recently, two X-SCID patients treated by gene therapy to rescue T-cell lymphopoiesis developed T-cell leukemias with retroviral insertion into the LMO2 gene causing clonal T-cell proliferation. In view of the specificity of LMO2 in T-cell tumorigenesis, we investigated a possible role for Lmo2 in T-lymphopoiesis, using conditional knockout of mouse Lmo2 with loxP-flanked Lmo2 and C...

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Authors: McCormack, M; Forster, A; Drynan, L; Pannell, R; Rabbitts, T

• Journal: Molecular and cellular biology
• Volume: 23
• Issue: 24
• Pages: 9003-9013
• Publication date: 2003-12-01
• DOI: 10.1128/mcb.23.24.9003-9013.2003
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: T-Lymphocytes; Proto-Oncogene Proteins; Adaptor Proteins, Signal Transducing; Metalloproteins; DNA; Mice, Knockout; Animals; LIM Domain Proteins; Retroviridae; Translocation, Genetic; DNA-Binding Proteins; Base Sequence; Gene Expression Regulation; Lymphopoiesis; Humans; Genetic Therapy; Gene Deletion; Cell Differentiation; Leukemia, T-Cell; Mice; Oncogenes