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The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.

Abstract:

The LMO2 gene encodes a LIM-only protein and is a target of chromosomal translocations in human T-cell leukemia. Recently, two X-SCID patients treated by gene therapy to rescue T-cell lymphopoiesis developed T-cell leukemias with retroviral insertion into the LMO2 gene causing clonal T-cell proliferation. In view of the specificity of LMO2 in T-cell tumorigenesis, we investigated a possible role for Lmo2 in T-lymphopoiesis, using conditional knockout of mouse Lmo2 with loxP-flanked Lmo2 and C...

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Authors


McCormack, MP More by this author
Forster, A More by this author
Pannell, R More by this author
Rabbitts, TH More by this author
Journal:
Molecular and cellular biology
Volume:
23
Issue:
24
Pages:
9003-9013
Publication date:
2003-12-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:b8acfa2e-720c-47f2-8351-d230eb9003de
Source identifiers:
324278
Local pid:
pubs:324278

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