Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.

Journal article

Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2K(b)-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K(b)-specific T cells than either skin or islet allografts. Rejection of all three types o...

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Authors: Jones, N; Turvey, SE; Van Maurik, A; Hara, M; Kingsley, C

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 166
• Issue: 4
• Pages: 2824-2830
• Publication date: 2001-02-01
• DOI: 10.4049/jimmunol.166.4.2824
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Lymphocyte Count; T-Lymphocytes, Cytotoxic; Immunologic Memory; Cell Movement; Mice; Lymphocyte Activation; Islets of Langerhans Transplantation; Male; Organ Transplantation; Animals; Lymph Nodes; Disease Susceptibility; Epitopes, T-Lymphocyte; Heart Transplantation; H-2 Antigens; Immune Tolerance; Mice, Inbred C57BL; T-Lymphocyte Subsets; Mice, Inbred CBA; Graft Rejection; Mice, Transgenic; Skin Transplantation; Postoperative Period; Transplantation, Homologous; Isoantigens