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Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family.

Abstract:

One of the principal aims of modern drug design is the targeted delivery of drugs within the body, such as to the central nervous system, combined with their exclusion from the liver and kidneys, which break down foreign molecules and subsequently eliminate them. Many of the commonly prescribed drugs are transported into cells and across the plasma membrane via endogenous membrane transporters, whose principal roles are the uptake of essential nutrients for metabolism. In many cases, such dru...

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Publication status:
Published

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Publisher copy:
10.1042/bst0391353

Authors


Newstead, S More by this author
Journal:
Biochemical Society transactions
Volume:
39
Issue:
5
Pages:
1353-1358
Publication date:
2011-10-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:b89672b6-cf6e-4d50-a8de-85e7e19e88c2
Source identifiers:
205864
Local pid:
pubs:205864

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