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Thesis

Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

Abstract:

Integral membrane proteins are responsible for a wide range of cellular functions and are important targets for the development of novel therapeutics. Therefore, obtaining structural and mechanistic insights into their function is of central importance for rational drug design. In this thesis, I focused on characterising three human integral membrane proteins using X-ray crystallography, cryo-EM, mass spectrometry and other biochemical methods.

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Division:
MSD
Department:
NDM
Sub department:
CM CMD
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0003-3375-4207

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Supervisor
ORCID:
0000-0001-9138-2937
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
ORCID:
0000-0002-6635-3621
Institution:
Newcastle University
Role:
Supervisor
ORCID:
0000-0001-6959-6007
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CM CMD
Role:
Supervisor
ORCID:
0000-0001-9661-2607
More from this funder
Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Funding agency for:
da Costa Cabral Gomes Páscoa, T
Grant:
102164/B/15/Z
Programme:
Wellcome Trust-funded DPhil in Cellular Structural Biology
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:
Language:
English
Subjects:
Deposit date:
2023-02-08

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