Journal article icon

Journal article

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.

Abstract:

Lipids are thought to serve as coupling factors in insulin secretion. Hormone-sensitive lipase (HSL) is expressed in pancreatic beta-cells and could potentially regulate insulin secretion via mobilization of stored triglycerides. Here, we examined the impact of HSL deficiency on fuel metabolism and insulin secretion in mouse islets. Lack of HSL resulted in abrogation of neutral cholesterol ester hydrolase activity, whereas diglyceride lipase activity remained intact. Although glucose stimulat...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1210/en.2003-1673

Authors


Olofsson, CS More by this author
Fransson, U More by this author
Lindvall, H More by this author
Expand authors...
Journal:
Endocrinology
Volume:
145
Issue:
8
Pages:
3746-3753
Publication date:
2004-08-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:b882dd21-2fbd-4c5b-989c-6858a5ff9519
Source identifiers:
12770
Local pid:
pubs:12770

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP