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Journal article

Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines.

Abstract:

Improving vaccine immunogenicity remains a major challenge in the fight against developing country diseases like malaria and AIDS. We describe a novel strategy to identify new DNA vaccine adjuvants. We have screened components of the Toll-like receptor signalling pathways for their ability to activate pro-inflammatory target genes in transient transfection assays and assessed in vivo adjuvant activity by expressing the activators from the DNA backbone of vaccines. We find that a robust increa...

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Publication status:
Published

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Authors


Larsen, KC More by this author
Spencer, AJ More by this author
Goodman, AL More by this author
Gilchrist, A More by this author
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Journal:
Vaccine
Volume:
27
Issue:
41
Pages:
5589-5598
Publication date:
2009-09-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:b88185cd-c0c3-4793-8416-fad145787afa
Source identifiers:
34813
Local pid:
pubs:34813

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