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Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

Abstract:

Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom...

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Publisher copy:
10.1093/hmg/ddu431

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Journal:
Human molecular genetics
Volume:
24
Issue:
1
Pages:
285-298
Publication date:
2015-01-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:b86f21d6-4efc-4f13-9837-a9bb2ca4ab96
Source identifiers:
482482
Local pid:
pubs:482482

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