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Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.

Abstract:

BACKGROUND: Interleukin-12 (IL-12) and related cytokines induce activation and differentiation of T cells. Our aim was to investigate the associations between genetic differences in IL-12-family cytokines and the pathogenesis of chlamydial disease. METHODS: The final study population consisted of 100 women with Chlamydia trachomatis-induced tubal factor infertility (TFI) and 125 pregnant women as controls. Three single nucleotide polymorphisms (SNPs) of IL12A and seven SNPs of IL12B genes wer...

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Publication status:
Published

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Publisher copy:
10.1093/humrep/des136

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Journal:
Human reproduction (Oxford, England)
Volume:
27
Issue:
7
Pages:
2217-2223
Publication date:
2012-07-05
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
URN:
uuid:b8613203-7b98-4809-aace-d7c6ae7dd263
Source identifiers:
332770
Local pid:
pubs:332770

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