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A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

Abstract:

Homotypic adhesion by phorbol ester-stimulated lymphocytes requires LFA-1 and Mg+2 and does not involve like-like interactions between LFA-1 molecules on adjacent cells. The latter finding suggested that a second molecule, distinct from LFA-1, also participates in LFA-1-dependent adhesion. The identification of such a molecule was the object of this investigation. After immunization with LFA-1-deficient EBV-transformed lymphoblastoid cells, a MAb was obtained that inhibits phorbol ester-stimu...

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Authors


Rothlein, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Marlin, SD More by this author
Springer, TA More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
137
Issue:
4
Pages:
1270-1274
Publication date:
1986-08-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:b856ddef-1b1b-4d55-9983-c3893431e527
Source identifiers:
482727
Local pid:
pubs:482727

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