Journal article icon

Journal article

Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

Abstract:

IL-18 inhibits osteoclast (OCL) formation in vitro independent of IFN-gamma production, and this was abolished by the addition of neutralizing antibodies to GM-CSF. We now establish that IL-18 was unable to inhibit OCL formation in cocultures using GM-CSF-deficient mice (GM-CSF -/-). Reciprocal cocultures using either wild-type osteoblasts with GM-CSF -/- spleen cells or GM-CSF -/- osteoblasts with wild-type spleen cells were examined. Wild-type spleen cells were required to elicit a response...

Expand abstract

Actions


Access Document


Publisher copy:
10.1172/jci1333

Authors


Horwood, NJ More by this author
Udagawa, N More by this author
Elliott, J More by this author
Okamura, H More by this author
Expand authors...
Journal:
The Journal of clinical investigation
Volume:
101
Issue:
3
Pages:
595-603
Publication date:
1998-02-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:b856851c-9ec9-4684-9d41-dbdfe1169780
Source identifiers:
429438
Local pid:
pubs:429438

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP