- Abstract:
-
IL-18 inhibits osteoclast (OCL) formation in vitro independent of IFN-gamma production, and this was abolished by the addition of neutralizing antibodies to GM-CSF. We now establish that IL-18 was unable to inhibit OCL formation in cocultures using GM-CSF-deficient mice (GM-CSF -/-). Reciprocal cocultures using either wild-type osteoblasts with GM-CSF -/- spleen cells or GM-CSF -/- osteoblasts with wild-type spleen cells were examined. Wild-type spleen cells were required to elicit a response...
Expand abstract - Publisher copy:
- 10.1172/jci1333
-
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- Journal:
- The Journal of clinical investigation
- Volume:
- 101
- Issue:
- 3
- Pages:
- 595-603
- Publication date:
- 1998-02-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:b856851c-9ec9-4684-9d41-dbdfe1169780
- Source identifiers:
-
429438
- Local pid:
- pubs:429438
- Copyright date:
- 1998
Journal article
Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.
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