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Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.

Abstract:

No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induced antibodies. Here we show that antibodies against PfRH5 efficiently inhibit the in vitro growth of short-term-adapted parasite isolates from Cambodia, and that the EC(50) values of antigen-specif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1002991

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
More from this funder
Name:
Career Development
Funding agency for:
Draper, S
Grant:
G1000527
More from this funder
Name:
Sanger Institute
Funding agency for:
Kwiatkowski, D
Grant:
G0600718
More from this funder
Name:
Medical Research Council
Funding agency for:
Miotto, O
Kwiatkowski, D
Grant:
G0600718
G0600718
More from this funder
Name:
Wellcome Trust
Funding agency for:
Douglas, A
Illingworth, J
Grant:
089455/2/09/z
092873/z/10/z
More from this funder
Name:
EVIMalaR
Grant:
242095
Publisher:
Public Library of Science
Journal:
PLoS pathogens More from this journal
Volume:
8
Issue:
11
Pages:
e1002991-e1002991
Publication date:
2012-11-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7374
Language:
English
Keywords:
UUID:
uuid:b854af0a-e4f3-4a13-9fe9-f93eb102431c
Local pid:
pubs:358668
Source identifiers:
358668
Deposit date:
2013-11-16

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