Journal article
Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
- Abstract:
-
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induced antibodies. Here we show that antibodies against PfRH5 efficiently inhibit the in vitro growth of short-term-adapted parasite isolates from Cambodia, and that the EC(50) values of antigen-specif...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Miotto, O
Kwiatkowski, D
Grant:
G0600718
G0600718
+ Wellcome Trust
More from this funder
Funding agency for:
Douglas, A
Illingworth, J
Grant:
089455/2/09/z
092873/z/10/z
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 8
- Issue:
- 11
- Pages:
- e1002991-e1002991
- Publication date:
- 2012-11-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7374
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:b854af0a-e4f3-4a13-9fe9-f93eb102431c
- Local pid:
- pubs:358668
- Source identifiers:
-
358668
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
- Notes:
-
file: :C$$:/Users/dominic/Dropbox/Refs/2012/Williams et al._2012_Enhancing blockade of Plasmodium falciparum erythrocyte invasion assessing combinations of antibodies against PfRH5 and other merozoite antigens.pdf:pdf
pmid: 23144611 This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Public Domain Dedication (CC0)
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