- Abstract:
-
To permit direct functional analyses of neural circuits, we have developed a method for stimulating groups of genetically designated neurons optically. Coexpression of the Drosophila photoreceptor genes encoding arrestin-2, rhodopsin (formed by liganding opsin with retinal), and the alpha subunit of the cognate heterotrimeric G protein--an explosive combination we term "chARGe"--sensitizes generalist vertebrate neurons to light. Illumination of a mixed population of neurons elicits action pot...
Expand abstract - Publisher copy:
- 10.1016/s0896-6273(01)00574-8
-
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- Journal:
- Neuron
- Volume:
- 33
- Issue:
- 1
- Pages:
- 15-22
- Publication date:
- 2002-01-05
- DOI:
- EISSN:
-
1097-4199
- ISSN:
-
0896-6273
- URN:
-
uuid:b852d875-9ac3-4722-8ab8-0bca049e9974
- Source identifiers:
-
322560
- Local pid:
- pubs:322560
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Selective photostimulation of genetically chARGed neurons.
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