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Selective photostimulation of genetically chARGed neurons.

Abstract:

To permit direct functional analyses of neural circuits, we have developed a method for stimulating groups of genetically designated neurons optically. Coexpression of the Drosophila photoreceptor genes encoding arrestin-2, rhodopsin (formed by liganding opsin with retinal), and the alpha subunit of the cognate heterotrimeric G protein--an explosive combination we term "chARGe"--sensitizes generalist vertebrate neurons to light. Illumination of a mixed population of neurons elicits action pot...

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Authors


Zemelman, BV More by this author
Miesenböck, G More by this author
Journal:
Neuron
Volume:
33
Issue:
1
Pages:
15-22
Publication date:
2002-01-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:b852d875-9ac3-4722-8ab8-0bca049e9974
Source identifiers:
322560
Local pid:
pubs:322560

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