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Structure and mechanism of drug efflux machinery in Gram negative bacteria.

Abstract:

In Gram-negative bacteria, multi-component machines that span the inner and outer membranes actively extrude drugs and other toxic small compounds. Many of these machines are assembled principally from three different types of components: i) an outer membrane protein that acts as a channel and opens from a sealed resting state during the transport process, ii) an inner membrane protein that transduces proton electrochemical energy into vectorial displacement of the transported compounds, and ...

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Publication status:
Published

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Publisher copy:
10.2174/138945008785747743

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
Journal:
Current drug targets More from this journal
Volume:
9
Issue:
9
Pages:
719-728
Publication date:
2008-09-01
DOI:
EISSN:
1873-5592
ISSN:
1389-4501
Language:
English
Keywords:
Pubs id:
pubs:156010
UUID:
uuid:b851d3db-df0b-41b4-b0a4-b36801aec421
Local pid:
pubs:156010
Source identifiers:
156010
Deposit date:
2012-12-19

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